Skip to content
Medx

Tag: Metabolite

Explore our medication guides and pharmacology articles within this category.

What is Norclozapine? Understanding Clozapine's Active Metabolite

•
4 min read
Norclozapine, also known as N-desmethylclozapine, is a major active metabolite of the atypical antipsychotic clozapine, and its concentration can vary significantly between individuals due to differences in metabolic factors. Understanding **what is norclozapine** is crucial for clinicians using therapeutic drug monitoring to optimize the treatment of conditions like treatment-resistant schizophrenia.

What Drug Has Cotinine in It? Understanding the Metabolite

•
4 min read
Over 70% of nicotine absorbed by the body is converted into cotinine, its main metabolite [1.2.3]. The pressing question for many is, **what drug has cotinine in it?** The answer is that no currently marketed drug contains cotinine as an active ingredient.

What is a Parent Drug? Understanding the Fundamentals of Pharmacology

•
5 min read
According to data from the US Food and Drug Administration (FDA), approximately 10% of all commercially available medicines worldwide are actually prodrugs that need conversion, highlighting the critical distinction between a prodrug and a **parent drug**. It is the initial, active chemical compound of a medication that the body is intended to metabolize.

What is the difference between toltrazuril and ponazuril?

•
6 min read
Ponazuril, also known as toltrazuril sulfone, is a major active metabolite of the drug toltrazuril, a key fact distinguishing these two widely used veterinary antiparasitic medications. This fundamental relationship leads to significant differences in their formulation, pharmacokinetics, approved uses across species, and overall clinical application.

Is Cotinine in Vapes? Understanding Nicotine's Key Metabolite

•
4 min read
Recent studies have shown that e-cigarette users exhibit significantly higher urinary cotinine levels than non-smokers. It is a common misconception that vaping, being different from smoking, might not result in the presence of cotinine in the body. This article clarifies that cotinine is not an ingredient in vapes but a major metabolite of nicotine, meaning anyone who vapes nicotine-containing products will have it in their system.