Which drug is never given in combination with methotrexate? The critical interaction you must know
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4 min read
Severe, even fatal, bone marrow suppression has been documented in patients combining the antibiotic trimethoprim-sulfamethoxazole (often sold as Bactrim) with methotrexate, even at low therapeutic doses. This information is critical for anyone prescribed methotrexate, as knowing which drug is never given in combination with methotrexate could prevent life-threatening complications.
