Tag: Methotrexate toxicity

Leucovorin is a reduced, active form of folate, while folic acid is a synthetic precursor that must be enzymatically converted in the body. This fundamental difference explains why use leucovorin instead of folic acid in critical clinical situations, such as counteracting the toxic effects of methotrexate therapy.

Folic acid can prevent a significant percentage of neural tube defects (NTDs) when taken appropriately, highlighting one of the most critical indications for folic acid therapy. This B vitamin is essential for numerous physiological processes, making its therapeutic use a cornerstone in treating several conditions related to cellular growth and division.

In studies of patients with rheumatoid arthritis, as many as 77.5% experience at least one adverse event when starting methotrexate. Knowing 'What are the red flag symptoms of methotrexate?' is crucial for patient safety.