Tag: Mitochondria

In mouse studies, obese mice treated with SLU-PP-332 gained ten times less fat and lost 12% of their body weight, all while eating the same amount of food. This exciting research points to a potential new class of metabolic drugs, as SLU PP 332 acts as an "exercise mimetic," mimicking the physiological benefits of physical activity at a cellular level.

Did you know that the synthetic peptide SS-31, also known as elamipretide, can accumulate within the mitochondria of cells at concentrations up to 5,000 times higher than in other cellular areas? This remarkable selectivity is key to understanding precisely what does SS 31 do, focusing its therapeutic effects on the cell's energy-producing powerhouse.

Statins, among the most prescribed medications for managing high cholesterol, are known to cause muscle-related side effects in some individuals. This has led to a major question in pharmacology: do statins really deplete CoQ10, and is this depletion the cause of common side effects like muscle pain?

While metformin is a highly effective and widely used medication for type 2 diabetes, the risk of metformin-associated lactic acidosis (MALA) is a rare but serious adverse event, with an incidence of about 5 cases per 100,000 in one analysis. This condition is primarily caused by a dual mechanism involving increased lactate production and reduced lactate clearance, especially when metformin accumulates in the body.

L-carnitine is a naturally occurring amino acid derivative that plays a crucial role in the body's energy production processes. A carnitine shot is an injection that delivers this compound directly into the bloodstream, used to support metabolism and fitness goals.

Some in vitro studies suggest astaxanthin's antioxidant capacity is significantly stronger than many other well-known antioxidants [1.2.2, 1.2.4]. This raises a common question for those seeking to combat oxidative stress: **is astaxanthin more powerful than CoQ10**, and which one offers superior benefits?

Over 7,000 naturally occurring peptides have been identified in the human body, acting as crucial signaling molecules [1.2.3]. The question, 'Do peptides give you energy?' is increasingly relevant as research shows they can enhance energy by targeting cellular processes, unlike temporary stimulants [1.3.3, 1.7.4].

In human studies, exercise has been shown to increase MOTS-c levels in skeletal muscle by as much as 11.9-fold. This fact underscores the peptide's role in metabolism and performance. For those using peptide therapy, the question remains: how long does MOTS-c take to work?

Regular CoQ10 has notoriously low bioavailability, meaning a large portion is poorly absorbed by the body. This raises the question: **Is MitoQ better than CoQ10?** In contrast, MitoQ is engineered to target the mitochondria directly, promising greater cellular impact and efficiency.

Some studies suggest that statin therapy can potentially attenuate the increase in maximal oxygen consumption ($VO_{2max}$) achieved through exercise training. However, the relationship between statins and $VO_{2max}$ is complex, with research producing conflicting results, leaving many patients and clinicians to question the impact of these vital cholesterol-lowering drugs on exercise performance.