Tag: Mitochondrial dysfunction

Research has demonstrated that a number of tricyclic antidepressants, including amitriptyline, can inhibit enzymes that require Coenzyme Q10 (CoQ10). While the link has been established, understanding the precise mechanisms behind why **does amitriptyline deplete CoQ10** is crucial for patients and healthcare providers managing long-term treatment. This interaction may have significant implications for cellular health, energy production, and heart function.

Following the FDA's accelerated approval in September 2025, elamipretide, now known as Forzinity, is the first approved treatment for Barth syndrome. Clinical trial data indicates that treatment duration for this chronic condition extends well beyond the initial study period, with some patients safely receiving the medication for several years.

While commonly prescribed for various infections, rare cases of adverse cardiac events have been reported with doxycycline. This has prompted questions and research into whether doxycycline can damage your heart under certain conditions, particularly with long-term, high-dose exposure.

Affecting up to 2% of patients treated with the anti-tuberculosis drug ethambutol, optic neuropathy (EON) is a serious and potentially irreversible side effect. It is a toxic optic neuropathy where the drug's damaging effects on the optic nerve cause inflammation and vision loss. Understanding **how does ethambutol cause optic neuritis** is crucial for early detection and preventing permanent visual impairment.

Mitochondrial dysfunction is a central factor in many age-related diseases and overall decline, leading to reduced energy and increased cellular damage. SS-31 peptide, also known as Elamipretide, is a groundbreaking, mitochondria-targeting compound designed to specifically address this root cause by stabilizing and optimizing mitochondrial function.

Following the accelerated FDA approval of elamipretide (SS-31) for Barth syndrome in September 2025, this novel mitochondria-targeted peptide has garnered significant attention for its role in cellular bioenergetics. SS-31's primary function is to protect and restore the function of damaged mitochondria, which are the cellular powerhouses responsible for energy production.