Tag: Mitotic inhibitors

Chemotherapy-induced peripheral neuropathy (CIPN) affects up to 60% of all cancer patients undergoing treatment with agents like mitotic inhibitors, with paclitaxel inducing it in up to 97% of certain patients. Mitotic inhibitors, a crucial class of chemotherapy drugs, are designed to halt the division of rapidly proliferating cancer cells, but their mechanism also affects healthy cells, leading to a range of significant side effects.

Mitotic spindle inhibitors are a class of anticancer drugs used in various chemotherapy regimens. These medications work by disrupting the cell's ability to undergo proper cell division, arresting the cell cycle in the M (mitosis) phase. So, what drugs are mitotic spindle inhibitors, and how do they function to stop cancer cell proliferation?