Tag: Mthfr mutation

According to one recent study, excess synthetic folic acid intake in people with the MTHFR C677T variant can lead to the accumulation of unmetabolized folic acid (UMFA), which is associated with cognitive and psychiatric issues. This critical genetic variation highlights the fundamental difference between the body's processing of synthetic folic acid and natural folate, and why avoiding folic acid with MTHFR is a key consideration for many people.

Over 60% of the US population may have a genetic mutation that affects folate metabolism, making methylfolate supplements a common consideration. However, it is crucial to understand what are the negative effects of methylfolate, which can range from mild discomfort to more serious health risks if not managed properly.

According to research, a significant portion of the population, estimated at 40-60%, carries a genetic variation that affects folate metabolism, specifically the MTHFR gene. This often leads to the important question: **How much methylfolate do I need daily?** The answer is not one-size-fits-all, as optimal intake is highly individual and depends on various factors, including your health status and genetic makeup.

According to the National Institutes of Health, high doses of folic acid may be unsafe for some people, especially those with certain underlying health conditions. Understanding who is not supposed to take folic acid is critical for preventing serious health complications that can arise from improper supplementation.

While Deplin is a prescription-only medical food, its active ingredient, L-methylfolate, is widely available over the counter (OTC) as a dietary supplement. Many individuals seek these OTC options as a more affordable or accessible alternative, particularly since health insurance often does not cover the high cost of Deplin.