Tag: Mu opioid receptors

In 2022, an estimated 9.37 million U.S. adults needed treatment for Opioid Use Disorder (OUD), but only 25.1% received recommended medications [1.10.1]. Understanding what Sublocade does to the brain is key to seeing its role in addressing this treatment gap by stabilizing brain chemistry [1.2.5].

An estimated 40% to 80% of patients receiving long-term opioid therapy experience opioid-induced constipation, a key symptom of broader gut dysfunction [1.6.1]. Understanding **how do opioids affect gastric emptying** is crucial to grasping why these powerful analgesics disrupt the digestive system so profoundly.

Initially believed to be a serotonin reuptake enhancer, modern research reveals that tianeptine’s therapeutic and recreational effects stem from a much more complex and unique set of actions in the brain. The drug's dual modulation of the opioid system and glutamate signaling provides a new perspective on how it exerts its effects.