Tag: Ndma

Starting in 2020, the U.S. Food and Drug Administration (FDA) initiated recalls for certain batches of extended-release (ER) metformin due to the presence of N-nitrosodimethylamine (NDMA) above acceptable limits. This action led to confusion about why is metformin being taken off the market, but it was a targeted safety measure by manufacturers, not a market-wide ban.

In 2020, the U.S. Food and Drug Administration (FDA) issued voluntary recalls for several lots of extended-release (ER) metformin due to contamination, not a nationwide ban. The action targeted specific batches from certain manufacturers that contained unacceptable levels of the impurity N-Nitrosodimethylamine (NDMA), a probable human carcinogen, but left other metformin products on the market.

In 2020, the FDA requested the complete withdrawal of all ranitidine products from the U.S. market, fueling widespread consumer concern about NDMA contamination. This action, along with earlier recalls of blood pressure drugs, raised a crucial question for millions of patients: **What medications have NDMA in them?**

The U.S. Environmental Protection Agency (EPA) has classified N-nitrosodimethylamine (NDMA) as a probable human carcinogen, based on evidence from animal studies. It is a toxic chemical that has garnered significant public attention due to its detection as an impurity in several common medications, leaving many to wonder what NDMA does to your body.

Before its market withdrawal in 2020, diarrhea was a recognized, though uncommon, side effect associated with ranitidine use. The medication, once widely known under the brand name Zantac, was prescribed for conditions like GERD and ulcers. Its removal from shelves, however, was prompted by a more serious discovery regarding potential cancer-causing impurities.

Several batches of generic amitriptyline have been recalled in recent years by regulatory bodies like Health Canada and Singapore's HSA due to quality control issues. Patients often ask, "Why was amitriptyline recalled?" to understand if their medication is affected, but it's important to differentiate specific batch recalls from the general safety profile of the medication itself.

Metformin is a widely prescribed medication, with tens of millions of prescriptions written annually in the US. Following a series of recalls involving N-Nitrosodimethylamine (NDMA) impurities in certain products, many patients have asked: **Is NDMA still in metformin?**

The active ingredient in Zantac, ranitidine, was entirely withdrawn from the market by the FDA in April 2020 due to potential contamination with the carcinogen NDMA. This has led many to question, 'Is nizatidine the same as zantac?'

In April 2020, the U.S. Food and Drug Administration (FDA) requested that all ranitidine products, including the popular brand-name Zantac, be pulled from the market. This action answers the question, **what antacid was discontinued?**, and followed an investigation that discovered a probable human carcinogen in the medication.

Gastroesophageal reflux disease (GERD), a primary condition treated by ranitidine, affects an estimated 20% of adults in the United States [1.9.1, 1.9.3]. So, **what is the main use of ranitidine?** It was principally used to decrease stomach acid for treating and preventing ulcers and GERD [1.2.1].