Tag: Neurogenesis

Chronic stress and major depressive disorder can significantly decrease neurogenesis in the hippocampus [1]. Emerging research is exploring what drugs induce neurogenesis to potentially counteract this effect and develop new treatments for psychiatric and neurological conditions [2, 3].

While the mature human brain has a limited capacity for regeneration, producing only a small number of new neurons each day primarily in the hippocampus, scientists are actively investigating what drugs are used to regenerate brain cells in damaged areas. The ultimate goal is to find therapeutic agents that can repair neurological damage caused by disease or injury.

Research has shown that several classes of drugs can stimulate the hippocampus, influencing brain functions related to memory and learning. While some substances provide acute stimulation that contributes to addiction, others, like certain antidepressants, promote lasting structural changes through neurogenesis. Understanding what drugs stimulate the hippocampus offers insight into both the mechanisms of addiction and potential therapeutic pathways for cognitive enhancement.

Affecting approximately 280 million people worldwide, depression is a common mental disorder [1.2.3]. Emerging research suggests that beyond correcting a chemical imbalance, the answer to 'Do antidepressants help rewire the brain?' lies in their ability to promote neuroplasticity [1.2.5, 1.4.1].

Recent preclinical animal studies have shown that the synthetic neurotrophic peptide P021, often referred to as p21 peptide, can promote neurogenesis and improve cognitive function. But what are the benefits of p21 peptide in detail, and what does the available research tell us about its potential therapeutic applications for neurodegenerative diseases and inflammation? This article explores the science behind this intriguing compound, highlighting its mechanisms and potential in medicine.

Recent neuroimaging studies show that classic psychedelics can induce a period of neuroplasticity, suggesting that ancient psychedelic compounds like ayahuasca may indeed help "rewire" the brain. Research into the brew's effects on brain function offers insight into its reported therapeutic potential for mood disorders and trauma.