Tag: Neurokinin

Affecting up to 80% of women during menopause, vasomotor symptoms (VMS) like hot flashes often prompt a search for alternative treatments. Neurokinin-3 receptor antagonist drugs, a novel non-hormonal option, specifically target and block a key signaling pathway in the brain's thermoregulatory center.

The neurokinin 2 (NK2) receptor, a member of the tachykinin receptor family, is predominantly found on smooth muscle in the periphery, including the gastrointestinal, respiratory, and urinary tracts. A range of compounds, known as neurokinin 2 receptor antagonists, have been developed to block the action of the endogenous ligand neurokinin A (NKA) at these receptors, though many have failed to reach the market despite initial promise.