Tag: Nexletol

Statins are the first-line therapy for most people with high cholesterol, but up to 30% of patients report intolerance, primarily due to muscle-related side effects. This raises a critical question: **Is Nexletol better than a statin** as an alternative treatment for lowering LDL cholesterol and reducing cardiovascular risk?

In clinical trials, diarrhea was one of the reasons for treatment discontinuation with Nexletol, affecting 0.4% of patients compared to 0.1% on placebo [1.2.1]. For those asking, **can Nexletol cause diarrhea?**, the data shows it is a recognized, though not highly common, side effect.

A 2022 meta-analysis of over 4 million patients found the overall prevalence of statin intolerance to be 9.1% [1.6.2]. For these individuals and others needing more aggressive cholesterol management, the key question is: **What is the new alternative to statins?** Several innovative drugs now offer powerful solutions.

In the landmark CLEAR Outcomes trial, which followed nearly 14,000 patients, bempedoic acid (the active ingredient in Nexletol) was found to be generally safe and well-tolerated, demonstrating a good benefit-to-risk ratio. As an alternative treatment for high cholesterol, understanding **how safe is Nexletol** is crucial for patients, especially those who cannot tolerate statins due to their side effects.

In the United States, nearly 28% of adults aged 40 to 59 have high cholesterol [1.10.1]. For those needing non-statin options, the question 'Which is better, Nexletol or Zetia?' is a critical one. Both medications offer unique pathways to lowering LDL cholesterol, but their suitability depends on individual patient factors.

Approximately 15 percent of people experience side effects, such as muscle aches, from statin medications, leading to discontinuation of treatment. This has fueled the development of newer alternatives, such as the **new cholesterol drug that is not a statin**, offering new hope for effective lipid management.