Tag: Nicotine metabolism

Cotinine, a major metabolite of nicotine, has a half-life of about 20 hours in the body, which is significantly longer than nicotine's few hours. This stability makes it an excellent biomarker for detecting tobacco use or secondhand smoke exposure. However, many health risks and side effects are mistakenly attributed to cotinine itself rather than the underlying nicotine exposure it indicates.

Nicotine from a product like a 6mg ZYN pouch is metabolized by the liver into cotinine, which has a significantly longer half-life of 16–19 hours compared to nicotine's 1-2 hours [1.2.1]. This article explains how long does the nicotine from a 6mg ZYN stay in your system.

According to the American Society of Anesthesiologists, smoking is a well-established risk factor for complications related to surgery and anesthesia. This is because the chemicals in tobacco profoundly impact multiple organ systems, creating significant challenges for anesthesiologists and increasing patient risk when you smoke and go under anesthesia.

Cotinine is the primary metabolite of nicotine and is used as a biomarker to determine a person's exposure to nicotine [1.2.5, 1.3.4]. This article explains the science behind cotinine testing, not how to avoid cotinine detection, as the only certain method is abstaining from nicotine.

Smoking is known to deplete the body's supply of essential nutrients like vitamin C [1.2.3]. While no single vitamin can instantly flush nicotine, understanding what vitamins flush nicotine out of your system can significantly support your body's natural metabolic and detoxification processes.