Tag: Nmda antagonists

Excessive levels of the excitatory neurotransmitter glutamate can be toxic to neurons, a process known as excitotoxicity, which is implicated in conditions like ALS and neurodegenerative disorders. Understanding **what drugs decrease glutamate levels** is vital for managing these conditions and is an active area of pharmacological research.

While both drugs act on the central nervous system, combining amantadine and memantine is typically cautioned against due to the risk of additive side effects. Manufacturers and health authorities warn of potential interactions that could intensify adverse effects, particularly those affecting the brain. However, some recent real-world studies, while limited, have not found robust statistical evidence for increased neuropsychiatric events, highlighting the need for careful clinical assessment on a case-by-case basis.

Glutamate is the most abundant excitatory neurotransmitter in the central nervous system, essential for synaptic plasticity, learning, and memory [1.2.3]. This article explores what medications block glutamate and their therapeutic applications in modern medicine.

Excessive glutamate levels can be toxic to neurons, a phenomenon known as excitotoxicity, which is implicated in a range of neurodegenerative and psychiatric disorders. Understanding what medications decrease glutamate levels is vital for therapeutic strategies targeting this imbalance and protecting neural health.