What medication does not cross the blood-brain barrier?: Examples and pharmacological reasons
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3 min read
Approximately 98% of small-molecule drugs and virtually all large-molecule drugs do not effectively cross the blood-brain barrier (BBB), presenting a significant pharmacological challenge for central nervous system therapies. The BBB is a highly selective barrier designed to protect the brain, and understanding **what medication does not cross the blood-brain barrier** is critical for both patient safety and therapeutic efficacy.
