Tag: Onj

While osteonecrosis of the jaw (ONJ) is a serious and rare side effect, studies indicate that its incidence with high-dose Xgeva (denosumab) used for cancer treatment is higher than previously thought and appears to increase with longer treatment duration. A significant risk of **osteonecrosis of the jaw with Xgeva** exists, especially in patients with pre-existing dental issues or those undergoing invasive dental procedures.

According to the FDA, Prolia carries a boxed warning regarding the increased risk of severe hypocalcemia, especially in patients with advanced chronic kidney disease. Knowing what you should not take with Prolia is vital to manage this risk and other potential drug interactions for safe treatment.