Tag: Oral absorption

According to the CDC, by 2024, approximately 1.8% of U.S. middle and high school students reported using nicotine pouches in the past 30 days. While the product is popular, many users wonder, why do ZYNs say upper lip? The answer lies in the pharmacology of oral nicotine absorption, which dictates that placement here provides the most comfortable, discreet, and effective experience.

Less than 1% of an oral dose of gentamicin enters the bloodstream, rendering it ineffective for systemic infections [1.5.3]. So, why is gentamicin not absorbed orally? The answer lies in its fundamental chemical properties that prevent it from crossing the gastrointestinal wall.

According to pharmacists, swallowing a troche is not a medical emergency, but it can significantly reduce the effectiveness of the medication because it bypasses the intended sublingual absorption pathway. This article explains why the route of administration is critical and why you should never swallow a troche.