Tag: Oral bioavailability

The injectable form of semaglutide, sold under brand names like Ozempic and Wegovy, is not designed for oral consumption, and drinking it results in virtually no therapeutic effect. It is crucial for patient safety to understand why drinking semaglutide is both ineffective and dangerous compared to taking it as prescribed.

First published in 1997, Lipinski's Rule of Five has since become a foundational principle in drug development, influencing how billions of dollars are spent in research. Understanding **why is Lipinski's rule important** is crucial for anyone in medicinal chemistry, as it helps predict a molecule's potential for oral bioavailability early in the discovery process.

Over 98% of circulating IGF-1 is bound to binding proteins and has a very short half-life in its free form, making it a challenging compound for effective delivery. So, can you take IGF-1 orally, or is it destined for degradation before it can have a systemic effect? For standard, free-form IGF-1, the answer is largely no, but ongoing research into novel delivery methods and the development of oral alternatives offer new insights.