Tag: Orap

In a 2014 retrospective review of 268 patients treated with the antipsychotic fluphenazine for Tourette's, 80.5% showed moderate tic improvement [1.9.1]. For severe cases unresponsive to standard therapies, the question arises: **what does pimozide do** as an alternative treatment? This antipsychotic works by altering brain chemistry to control symptoms [1.2.1, 1.2.2].

As a conventional antipsychotic, pimozide is used as a second-line treatment for severe Tourette's Disorder, particularly when a patient has not responded to or cannot tolerate other medications. **What is pimozide?** It is a neuroleptic drug that was developed at Janssen Pharmaceutica in 1963 and was approved by the FDA for Tourette's in 1984 under the Orphan Drug Act.