Why Does Penicillin Not Work Against E. coli?
•
5 min read
The vast majority of *Escherichia coli* (*E. coli*) strains are naturally resistant to the antibiotic penicillin, a phenomenon rooted in fundamental differences between Gram-positive and Gram-negative bacterial anatomy. This ineffectiveness is a critical concept in pharmacology, explaining why broad-spectrum alternatives or different drug classes are necessary for treating infections caused by this common bacterium.
