Tag: Overmethylation

An estimated one-third of people with depression have low folate levels, suggesting a significant link between this vital nutrient and mental well-being. Understanding if and why **methylfolate makes you feel good** involves exploring its role in brain chemistry, cellular function, and individual genetic factors.

Up to 40% of the population has an MTHFR gene mutation that can impact folate metabolism [1.7.1, 1.7.2]. This leads many to supplement with methylfolate, but how do you know if you're taking too much methylfolate and causing other issues?

Over 60% of the US population may have a genetic mutation that affects folate metabolism, making methylfolate supplements a common consideration. However, it is crucial to understand what are the negative effects of methylfolate, which can range from mild discomfort to more serious health risks if not managed properly.

While often well-tolerated, some individuals experience adverse reactions when taking methylfolate, with anecdotal evidence suggesting mood changes, anxiety, and headaches are possible. The severity of these reactions can vary widely, from temporary adjustment symptoms to more significant issues, making it important to understand what are the side effects of methylfolate before starting supplementation.