Tag: P gp inhibitor

Pharmacological studies have confirmed that several statins, including atorvastatin, are inhibitors of the efflux pump P-glycoprotein (P-gp) and may also be substrates for this transporter. A detailed understanding of these molecular interactions is crucial for managing potential drug-drug interactions and minimizing adverse effects. So, **is atorvastatin a P-gp inhibitor?** Yes, both *in vitro* and clinical data suggest it has P-gp inhibitory properties.

Research in cell models has demonstrated that omeprazole and other proton-pump inhibitors can act as inhibitors of P-glycoprotein (P-gp). This discovery is important for understanding potential drug-drug interactions involving omeprazole and a wide range of medications that are P-gp substrates.