Tag: P gp inhibitors

P-glycoprotein (P-gp) is responsible for a major mechanism of chemotherapy resistance, a phenomenon that can severely hinder the effectiveness of cancer treatment. As such, understanding and inhibiting this efflux pump has become a key strategy in pharmacology. Numerous medications and natural products, often categorized into generations, serve as **examples of P-gp inhibitors**.

Overexpression of P-glycoprotein (P-gp) in cancer cells is a primary cause of multidrug resistance, a major hurdle in chemotherapy. Understanding **which drugs inhibit P-glycoprotein** is crucial for optimizing drug efficacy, overcoming resistance, and preventing adverse drug interactions.