Tag: P2y12 inhibitor

Each year in the U.S., an estimated 1.2 million people are hospitalized with acute coronary syndromes (ACS) [1.7.3]. For these patients, potent medications are crucial. But **is ticagrelor a strong blood thinner?** This medication plays a vital role in modern cardiology for preventing life-threatening clots.

Following a 180mg loading dose, ticagrelor begins to inhibit 41% of platelets within just 30 minutes, a significantly faster onset than older antiplatelet agents [1.2.1, 1.3.3]. Understanding **how fast does ticagrelor work** is crucial in emergency cardiac situations.

Clopidogrel, known by the brand name Plavix®, is primarily prescribed as an antiplatelet medication to prevent blood clots in high-risk patients. However, some research has shown that platelet inhibition with clopidogrel is also associated with a reduction of inflammation, though it is not classified as a conventional anti-inflammatory.

Clinical trials like PEGASUS-TIMI 54 have demonstrated that the long term use of ticagrelor can significantly reduce the rate of major adverse cardiovascular events in high-risk patients with a prior heart attack. This approach is an extension of the initial standard dual antiplatelet therapy (DAPT) protocol, which typically lasts for a certain period following an acute coronary syndrome (ACS).

Ticlopidine was notably associated with a risk of severe hematological adverse reactions, such as neutropenia and thrombotic thrombocytopenic purpura (TTP), which ultimately led to its discontinuation in the United States and other regions. This article details what type of drug is ticlopidine, its mechanism of action, and why it is no longer widely used.

Guidelines from the American College of Cardiology/American Heart Association recommend dual antiplatelet therapy (DAPT), often including ticagrelor, for at least 12 months after an Acute Coronary Syndrome (ACS) [1.3.1]. The crucial question for many patients is, **how long can you take ticagrelor** after this initial period?

Brilique, with its active substance ticagrelor, is a potent antiplatelet medication that prevents blood clots by inhibiting platelet aggregation. The key to its rapid and effective action lies in a unique mechanism, distinguishing it from older medications like clopidogrel. So, what is the mechanism of action of brilique?