Tag: Paliperidone

While comparative studies have shown similar overall efficacy between olanzapine and paliperidone for treating schizophrenia, significant differences in side effect profiles and available formulations distinguish the two. The question of which is better, olanzapine or paliperidone, is not simple and depends on individual patient response and tolerability.

Yes, paliperidone is available in tablets, specifically as an extended-release (ER) oral formulation under the brand name Invega®. This is a once-daily medication designed to release the active compound, paliperidone, slowly over a 24-hour period.

According to Drugs.com, Abilify (aripiprazole) has a user rating of 6.1 out of 10, while Invega (paliperidone) has a lower rating of 4.8, based on different user experiences. When comparing which is better, Invega or Abilify, it is crucial to understand that effectiveness and tolerability vary significantly based on an individual's specific condition and physiological response.

As an atypical antipsychotic, Invega (paliperidone) functions as a dopamine receptor antagonist, primarily blocking dopamine D2 receptors in the brain. This action is contrary to increasing dopamine, as it actually reduces the effects of dopamine to manage conditions like schizophrenia and schizoaffective disorder.

In clinical trials for the extended-release tablet form of Invega (paliperidone), somnolence (drowsiness) was reported in up to 26% of patients [1.3.4]. Understanding this common side effect is crucial for anyone prescribed this medication. So, **does Invega make you sleepy**, and what can be done about it?

Improving medication adherence is a key benefit of long-acting antipsychotics. For individuals on this medication, a common question is, can paliperidone be given in the arm? The answer depends on the specific formulation and treatment phase, as injection protocols specify deltoid (arm) or gluteal (buttock) administration.

Paliperidone is the major active metabolite of risperidone, a fact that dictates most of the key differences between the two drugs. While the two medications share a similar mechanism of action, their unique metabolic pathways, available formulations, and slightly different side effect profiles distinguish them clinically.

In a study of adolescents treated with paliperidone, 50% reported adverse drug reactions, with weight gain being the most common [1.8.2]. If you're wondering, 'What can you take instead of Invega?', it's important to explore other atypical antipsychotics with your healthcare provider.

While most medications are metabolized by the liver, approximately 60% of a single oral dose of paliperidone is eliminated unchanged via the kidneys. This unique pharmacological profile provides important clinical advantages and directly answers the question: is paliperidone in the liver or kidneys?

Yes, paliperidone is primarily renally cleared, with studies showing that approximately 59% of an administered dose is excreted unchanged in the urine. The kidneys play a major role in its elimination from the body, a key fact for clinicians to consider when prescribing this medication. This is particularly important for patients with compromised kidney function, as reduced renal clearance can lead to higher plasma concentrations and an increased risk of side effects.