Tag: Pancreatic enzyme replacement therapy

Cystic Fibrosis (CF) affects approximately 100,000 people worldwide [1.7.1, 1.7.2]. A key question in its management is, **which enzyme is used to treat cystic fibrosis?** The answer involves two main types of enzyme therapies targeting different symptoms: dornase alfa for the lungs and pancreatic enzymes for digestion.

Zenpep has been on the market for more than 15 years, receiving its initial FDA approval on August 27, 2009, for the treatment of exocrine pancreatic insufficiency (EPI). This milestone marked a significant regulatory shift for pancreatic enzyme products.

According to Mayo Clinic research, prescription pancreatic enzyme products, which contain amylase, are derived from the pancreas of pigs and can cause serious allergic reactions in some individuals. It is critical to understand who should not take amylase before using any supplement, especially those derived from animal sources, to avoid severe health complications.