Tag: Parasite resistance

First appearing in veterinary parasites soon after its widespread use, **ivermectin resistance** is now a well-documented and growing concern across multiple species. This challenge affects both animal health and, increasingly, raises questions for human public health programs, threatening the long-term effectiveness of a vital antiparasitic drug.

Ivermectin's effectiveness is based on its targeted action against specific invertebrate nerve and muscle cells; however, certain classes of parasites inherently lack this molecular target. This limitation means some parasites are naturally resistant, while others have developed resistance through evolutionary pressure. This article details what parasites are not affected by ivermectin and the critical reasons behind its limitations.