Tag: Paromomycin

Cutaneous leishmaniasis affects an estimated 0.7 to 1.2 million people annually across nearly 100 countries, making effective and simple treatments crucial. For the localized skin infection, the primary answer to the question, 'What is the ointment for leishmaniasis?' involves paromomycin-based topical creams, which have demonstrated significant efficacy in clinical trials. These creams offer a less toxic and more convenient alternative to traditional systemic therapies.

Paromomycin is an antimicrobial used for several parasitic infections, including amebiasis and giardiasis [1.2.5]. When considering if **is paromomycin safe in pregnancy**, the primary factor is its poor absorption from the gastrointestinal tract, which minimizes fetal exposure [1.2.1].

While the brand name version of paromomycin, Humatin, has been discontinued in the U.S., the generic antibiotic itself remains available for treating certain parasitic infections [1.2.5, 1.4.2]. This distinction is central to answering the query: 'Why is paromomycin discontinued?'.

Diarrhea is one of the most common gastrointestinal side effects associated with taking the antibiotic paromomycin. The risk of developing this side effect is particularly higher with larger doses, specifically those exceeding 3 grams per day.

First approved for medical use in 1960, the aminoglycoside antibiotic Paromomycin, commonly known by the brand name Humatin, is poorly absorbed by the body, allowing it to act directly within the intestines. This unique property explains **what is the drug Paromomycin used for**—primarily for treating intestinal parasitic infections and managing hepatic encephalopathy.

An estimated 600,000 to 1 million new cases of cutaneous leishmaniasis occur worldwide annually [1.2.4]. When considering what ointment is good for cutaneous leishmaniasis, topical formulations of paromomycin have shown significant efficacy in clinical trials and are a primary option [1.4.5].

Unlike many common antibiotics, the vast majority of aminoglycosides are not absorbed effectively from the gastrointestinal (GI) tract when taken by mouth, making the question, 'Is aminoglycoside oral?', a critical one for understanding their specific applications. The choice of administration route depends entirely on whether the desired effect is systemic or localized to the gut.