Tag: Pegylation

With over 30 FDA-approved PEGylated drugs on the market, PEGylation is a proven method for improving biopharmaceutical properties. This process involves attaching polyethylene glycol (PEG) chains to therapeutic molecules to explain what are the benefits of PEGylation for drug efficacy and safety.

While PEGylation has dramatically improved the stability and half-life of many biopharmaceuticals, a targeted literature review of PEGylated therapeutics reveals potential adverse outcomes, including increased drug clearance and decreased activity. Concerns regarding immunogenicity and patient safety have led to a critical re-examination of what are the drawbacks of PEGylation.

As one of the most widely utilized compounds in both consumer and medical products, polyethylene glycol (PEG) serves a surprisingly diverse set of functions in the body. From treating occasional constipation to revolutionizing targeted drug delivery systems, what does PEG do to your body depends entirely on its molecular weight and intended use. Its low toxicity and high water solubility make it an invaluable tool in modern medicine.