Tag: Peptide degradation

Peptides are generally more stable in lyophilized (freeze-dried) form than in solution [1.2.4]. Understanding the factors that affect their lifespan is crucial, so **how long will peptides last?** The answer depends entirely on their form and storage conditions.

According to U.S. Pharmacopeia (USP) guidelines, multi-dose sterile injectable preparations typically have a beyond-use date (BUD) of 28 days once punctured. Understanding what happens if you use compounded semaglutide after 28 days is crucial for ensuring the medication's effectiveness and your personal safety.

According to the FDA, drugs used beyond their expiration date have no guaranteed safety or efficacy, making the use of expired compounded semaglutide a potential health gamble. This is especially critical for compounded versions, where stability is less predictable than with FDA-approved products.

Peptides are susceptible to various degradation pathways, including oxidation and hydrolysis [1.2.2]. Knowing **how to tell if peptides have gone bad** is crucial for ensuring their efficacy and safety, as improper storage or handling can render them ineffective or even harmful [1.7.1, 1.8.5].

According to pharmaceutical manufacturers, many injectable peptides must be stored in a refrigerator between 36°F and 46°F (2-8°C) to maintain their stability. If you don't refrigerate peptides, they are highly susceptible to degradation, leading to a loss of effectiveness and rendering them useless for their intended purpose.