Tag: Pethidine

Pethidine, also known as meperidine, is a synthetic opioid analgesic that was first synthesized in 1938 [1.4.5]. It is used for moderate to severe pain, but the answer to 'How does pethidine work?' reveals a complex profile with unique risks [1.4.5, 1.8.4].

By the mid-1970s, pethidine (meperidine) was a leading choice for pain management in many hospitals, but clinical guidelines have since shifted dramatically. This was driven by a deeper understanding of its toxic side effects, dangerous drug interactions, and the availability of superior alternatives, explaining why pethidine is no longer used for most clinical applications.

First synthesized in 1938 and approved for medical use in 1943, pethidine is a potent synthetic opioid pain medication used for the short-term relief of moderate to severe pain. It is also known by its US name, meperidine, and the brand name Demerol.