Tag: Pharmacogenomics

Approximately one-third of critically ill patients undergoing prolonged analgosedation experience “difficult sedation,” requiring larger-than-usual medication doses. This phenomenon highlights a complex interplay of genetic, physiological, and psychological factors that influence why sedation does not work for some people.

According to the Centers for Disease Control and Prevention (CDC), antimicrobial resistance is an urgent global public health threat, killing at least 1.27 million people worldwide in 2019. Understanding **what is it called when medication doesn't work** is crucial, as this phenomenon goes by several technical names and can stem from diverse and complex factors.

Multiple studies and systematic reviews have explored L-methylfolate's potential, with evidence suggesting that low serum and red blood cell folate levels are independent risk factors for major depressive disorder. L-methylfolate is the active form of folate and is being investigated to see if it can help depression, especially in cases where traditional treatments fall short.

Experts estimate that genetic factors alone can account for up to 95% of variability in how individuals respond to certain drugs. When you find yourself asking, 'Why is my body resisting medicine?,' the answer is often a complex interplay of biology, environment, and personal habits.

Over 90% of people carry at least one genetic variant that affects how their body processes medication [1.6.4]. If you've ever wondered, 'Why is my body not metabolizing medication?', the answer often lies in a combination of your unique genetics, health, and lifestyle.

According to research, approximately 50% of patients with chronic diseases do not take their medications as prescribed. If you find yourself asking, 'Why is my body not responding to medicine?' the answer is often complex and multi-faceted, involving factors far beyond just forgetting a dose.

It's estimated that more than 98% of people may have a genomic variant that could affect how they respond to commonly prescribed medications, according to the National Human Genome Research Institute. This genetic variation, among other factors, is a key reason many individuals ask, “Why am I resistant to medications?” when treatment fails to produce the expected results.

According to research, millions of Americans experience chronic pain daily. When medication that once provided relief becomes ineffective, the experience can be discouraging and frustrating, leading many to wonder, **what if my body is not responding to pain medication?** This guide explores the reasons behind this common issue and offers comprehensive strategies for effective management.

According to a systematic review, suboptimal pain management, or "oligoanalgesia," is a persistent issue in emergency departments, leading to poor patient outcomes. So, **what does it mean when painkillers don't work**? It's a complex issue stemming from numerous factors, requiring a re-evaluation of treatment strategies beyond simply increasing the amount of medication.

Up to 50% of undesirable drug reactions can be attributed to differences in how individuals metabolize medications. This variability is especially critical for antidepressants, where the cytochrome P450 (CYP) 2C19 enzyme plays a significant role in breaking down several commonly prescribed drugs. Understanding which antidepressants are metabolized by CYP2C19 is key to predicting efficacy, side effects, and optimizing treatment outcomes based on a person's unique genetic profile.