Tag: Phenothiazine

In 1954, Thorazine became the first antipsychotic medication approved by the U.S. Food and Drug Administration, marking a revolutionary shift in mental health treatment. The medication, known generically as chlorpromazine, dramatically changed the landscape of psychiatric care, influencing the deinstitutionalization movement by providing an effective pharmacological option for managing psychosis.

Propiomazine, a phenothiazine derivative, is primarily known for its potent sedative properties, with its central mechanism of action involving antagonism at multiple receptor sites in the central nervous system. First approved in 1960, the drug's effects stem from its ability to block key neurotransmitter receptors, leading to its clinical use in treating insomnia and providing sedation.

While oxomemazine is one of the most frequently prescribed antitussives in France, a 2024 systematic review published in *Clinical and Translational Allergy* found a lack of evidence regarding its clinical efficacy for cough treatment. This guide explores **what is oxomemazine used for**, its mechanism of action, therapeutic applications, and significant safety considerations.

First approved by the FDA in 1956, the brand name Compazine has since been discontinued in the U.S., but its generic form, prochlorperazine, remains in use. This medication is a first-generation antipsychotic with strong antiemetic properties, and understanding what's in Compazine is crucial for patients and healthcare providers alike.

Phenergan (promethazine) has been approved for medical use since 1951 and is a first-generation antihistamine with a variety of applications. Its primary functions include treating allergic reactions, preventing motion sickness, and controlling nausea and vomiting.

First introduced in 1957, Trilafon (perphenazine) is a first-generation antipsychotic primarily used for treating schizophrenia and severe nausea and vomiting. While the brand name is no longer manufactured in the U.S., the generic form is still prescribed for these and other off-label conditions.