How does phlorizin work? A look at its pharmacological mechanism
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4 min read
First isolated in 1835 from apple tree bark, phlorizin's primary mechanism is the non-selective competitive inhibition of sodium-glucose cotransporters (SGLTs). This action blocks glucose reabsorption in the kidneys and reduces intestinal glucose uptake, leading to glucose excretion in the urine and demonstrating a novel approach to glycemic control.
