What does milrinone do to heart rate? The complex effect of PDE3 inhibition
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4 min read
As a phosphodiesterase-3 (PDE3) inhibitor, milrinone increases cardiac contractility and causes vasodilation, but its direct effect on heart rate can be complex and variable. This medication is typically used for the short-term treatment of acute decompensated heart failure, yet a significant increase in heart rate, including serious arrhythmias, remains a known risk.
