Tag: Pio

Progesterone in oil (PIO) injections are often cited by patients undergoing fertility treatments as a source of significant discomfort and anxiety. For those wondering, yes, you can use numbing cream for progesterone shots, and it is a common and effective strategy recommended by healthcare providers to alleviate injection site pain.

While pain experiences vary widely, studies and patient reports indicate that progesterone in oil (PIO) injections can cause significant soreness and discomfort, often likened to the deep muscle ache after an intense workout. This article explores why the shots can be painful and provides effective strategies to manage **how bad do progesterone shots hurt** during fertility treatments.