Tag: Pitolisant

First discovered in 1983, the histamine H3 receptor is primarily found in the brain, differentiating it from H1 and H2 receptors and making its modulation valuable for central nervous system disorders. This unique role has led to the development of specific drugs that are H3 receptor antagonists to influence neurological functions.

According to clinical trial data, Pitolisant, a selective H3 receptor antagonist/inverse agonist, has been shown to effectively reduce excessive daytime sleepiness and cataplexy in adult patients with narcolepsy. Pitolisant is a prime example of a h3 receptor antagonist, a class of drugs with a unique mechanism of action focused on modulating histamine in the brain.

Affecting an estimated 4-6% of the population, hypersomnia, or oversleeping, is a condition with significant impacts on daily life [1.3.1, 1.3.2]. If you're wondering what medication is used to stop oversleeping, several pharmacological options are available to promote wakefulness and manage symptoms.