Tag: Plasma protein binding

Approximately 97% of the anticoagulant warfarin is bound to plasma proteins, making it a classic example of what drugs are restrictively cleared. This pharmacokinetic concept is essential for understanding how certain medications are eliminated from the body and why their clearance is highly dependent on factors like plasma protein levels and intrinsic metabolic capacity.

Up to 99% of some drugs, such as the anticoagulant warfarin, are highly bound to proteins circulating in the blood plasma. Understanding **what drugs bind to plasma** is a foundational concept in pharmacology that determines a medication's availability, distribution throughout the body, and potential for significant drug interactions.

Over half of the 100 most prescribed drugs in the United States are more than 90% plasma protein bound [1.5.3]. Understanding **what drugs are plasma bound** is crucial for grasping their efficacy, potential for interactions, and overall effect on the body [1.5.2, 1.3.1].