Tag: Polarity

Less than 1% of an oral dose of gentamicin enters the bloodstream, rendering it ineffective for systemic infections [1.5.3]. So, why is gentamicin not absorbed orally? The answer lies in its fundamental chemical properties that prevent it from crossing the gastrointestinal wall.

A remarkable 98% of small-molecule drugs and 100% of large-molecule biopharmaceuticals cannot effectively cross the blood-brain barrier (BBB), a sophisticated protective layer designed to keep harmful substances away from the brain. This creates a significant challenge for therapeutics, raising the critical question of which drug cannot pass the blood-brain barrier and why.