What are the drawbacks of PEGylation? A critical look at the challenges for medications and pharmacology
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3 min read
While PEGylation has dramatically improved the stability and half-life of many biopharmaceuticals, a targeted literature review of PEGylated therapeutics reveals potential adverse outcomes, including increased drug clearance and decreased activity. Concerns regarding immunogenicity and patient safety have led to a critical re-examination of what are the drawbacks of PEGylation.
