Tag: Post antibiotic effect

Metronidazole has an average elimination half-life of about eight hours, meaning it takes this long for the drug's concentration in the blood to reduce by half [1.3.2]. So, does metronidazole keep working after you stop taking it? While some effects linger, its ability to fight infection quickly diminishes.

Aminoglycosides are potent antibiotics known for their effectiveness against serious bacterial infections. As powerful antibiotics that target the bacterial ribosome, their action is decidedly bactericidal—meaning they kill bacteria rather than just inhibiting their growth. Their unique bactericidal properties, combined with concentration-dependent killing, inform how they are used in clinical practice.

Aminoglycosides are one of the few classes of protein synthesis inhibitors that are bactericidal, not merely bacteriostatic. This powerful and rapid killing effect is primarily due to their irreversible binding to the bacterial ribosome, causing widespread cellular dysfunction.