Tag: Ppar alpha

While fenofibrate is primarily known as a lipid-lowering medication for hypercholesterolemia and hypertriglyceridemia, preclinical research suggests that it also exerts several pharmacological effects on the central nervous system (CNS). These intriguing effects stem from its primary mechanism of action: activating the nuclear receptor peroxisome proliferator-activated receptor alpha ($$PPAR-\alpha$$).

Fenofibrate, a drug primarily known for treating high cholesterol and triglycerides, has been shown to reduce systemic inflammation markers like C-reactive protein (hsCRP) by nearly 50% in patients with metabolic syndrome. This powerful effect suggests that fenofibrate is an anti-inflammatory agent, exerting benefits beyond its standard lipid-modulating actions.

An estimated 94 million US adults have high cholesterol, a major risk factor for heart disease. For those with elevated lipids that do not respond to diet and exercise alone, a doctor may prescribe the drug Tricor, which is used to help lower cholesterol and triglycerides in the blood.

First isolated from lipid fractions of egg yolks in 1957, palmitoylethanolamide (PEA) has been studied for its potent anti-inflammatory and analgesic properties for decades. Today, many ask, "what is palmitoylethanolamide used for?" as it gains attention as a dietary supplement for various chronic inflammatory and pain conditions.