Tag: Protein binding

Despite being a common local anesthetic and antiarrhythmic, the clearance of lidocaine by hemodialysis is negligible. This is a crucial point for managing patients with kidney failure, where understanding *is lidocaine cleared by dialysis?* informs critical dosing decisions.

Riluzole is approximately 96% bound to plasma proteins, primarily albumin and lipoproteins [1.2.1, 1.3.2]. This high level of protein binding is a critical factor influencing its movement throughout the body. Understanding this, we can ask: what is the distribution of riluzole in human tissues?

Naproxen, a common nonsteroidal anti-inflammatory drug (NSAID), is known to cross the blood-brain barrier (BBB), but its high plasma protein binding significantly restricts the amount of free drug that enters the central nervous system (CNS). This limited brain penetration is a key factor in its pharmacological profile, balancing peripheral pain relief with potential CNS side effects.