Tag: Psychological factors

Research indicates that as many as two-thirds of patients with major depressive disorder may not achieve full symptom remission with the initial prescribed medication. This phenomenon, often termed an inadequate response to antidepressants or treatment-resistant depression, can be attributed to a complex interplay of clinical, biological, and patient-related factors.

According to a systematic review, suboptimal pain management, or "oligoanalgesia," is a persistent issue in emergency departments, leading to poor patient outcomes. So, **what does it mean when painkillers don't work**? It's a complex issue stemming from numerous factors, requiring a re-evaluation of treatment strategies beyond simply increasing the amount of medication.