Understanding the Mechanism: How Does Pyrazinamide Cause Hyperuricemia?
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4 min read
Hyperuricemia, or elevated uric acid, occurs in 43% to 100% of patients treated with the tuberculosis medication pyrazinamide [1.2.2]. Understanding **how does pyrazinamide cause hyperuricemia?** involves examining its primary metabolite and its effect on kidney transporters, which significantly reduces the renal clearance of uric acid [1.2.2].
