Tag: Qtc prolongation

Amitriptyline, a tricyclic antidepressant (TCA), is known for its cardiotoxic potential, which has historically led to a high fatality rate in poisoning cases involving this drug class. The cardiovascular effects of amitriptyline are a critical consideration for both prescribers and patients due to its complex pharmacology.

According to research on drug interactions, taking hydroxychloroquine (Plaquenil) can potentially increase the blood levels and effects of duloxetine (Cymbalta). This means that while combining these medications might be necessary for certain conditions, a patient must consult with their doctor to manage the potential risks associated with taking Plaquenil and Cymbalta together.

While not a common side effect at therapeutic doses, a 2017 case study reported a patient who ingested a significant baclofen overdose and developed QTc prolongation, highlighting a specific risk scenario. This potential for cardiac complications primarily emerges in cases of toxicity, so **does baclofen prolong QTC** is not a concern for most standard prescribed uses.