Tag: Rapamune

The oral bioavailability of sirolimus is notably low and variable, leading many to believe that intravenous (IV) administration is not possible. However, in a significant development, a distinct protein-bound formulation of intravenous sirolimus was approved by the FDA in November 2021 for the treatment of a specific type of cancer, proving that yes, sirolimus can be given IV. This specialized IV use is distinctly different from the long-standing oral versions of the drug.

According to clinical trial data for renal transplant prophylaxis, headaches were reported as a very common side effect of sirolimus, with up to 34% of patients experiencing them. It is a well-documented and frequent adverse reaction to this medication.

In 1972, scientists isolated a powerful macrolide from soil samples on Easter Island, giving it the name rapamycin after the island's native name, Rapa Nui. This history is why answering "What is another name for rapamycin?" is not just about its generic name but also its intriguing origin story.

Yes, there is a generic for rapamycin, and it is widely available under the name sirolimus. The brand-name version, Rapamune, was discontinued in the U.S. in late 2023, making the generic form the primary option for patients.

As of December 31, 2023, Pfizer officially discontinued its brand-name drug Rapamune® in the United States, informing the Lymphangioleiomyomatosis (LAM) Foundation and healthcare providers. This decision impacts patients relying on the brand-name product, requiring them to transition to a generic equivalent, sirolimus.

According to the U.S. National Library of Medicine, sirolimus is a potent immunosuppressant crucial for preventing organ rejection after a kidney transplant and treating conditions like lymphangioleiomyomatosis (LAM). Understanding precisely **how to administer sirolimus** is therefore vital to ensure its effectiveness and maintain safe, stable blood levels.

With a retail price that can be discounted by over 90% using coupons, the answer to 'How much does rapamycin cost?' varies significantly [1.2.2]. The price depends on its form (brand or generic), dosage, and whether it's for an FDA-approved use or off-label purpose like anti-aging.