Tag: Rectal delivery

Rectal administration can bypass around two-thirds of the first-pass metabolism, allowing for greater bioavailability of many medications compared to the oral route. This guide explains how do you apply rectally for various medication types, including suppositories and enemas, with step-by-step instructions and important safety tips.

Dating back to antiquity, suppositories are an ancient dosage form that delivers medication to the body via the rectum or vagina. While perhaps less common today than oral pills, understanding what were suppositories used for reveals their enduring versatility in treating everything from constipation to severe nausea.

Approximately two-thirds of rectally administered medication can bypass the liver's first-pass metabolism, directly entering the systemic circulation. Understanding how is medicine absorbed rectally is crucial for appreciating this alternative drug delivery method for patients unable to take oral medications, such as those experiencing severe nausea or seizures.