Why is fidaxomicin preferred over vancomycin? A deep dive into CDI treatment
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3 min read
According to a 2021 guideline update by the Infectious Diseases Society of America (IDSA), fidaxomicin is the preferred treatment for initial and recurrent *Clostridioides difficile* infection (CDI). This shifts the long-standing practice of using vancomycin first-line. The primary reason behind this recommendation is the significant reduction in recurrence rates observed with fidaxomicin compared to vancomycin. So, **why is fidaxomicin preferred over vancomycin?**