Tag: Recurrent cdi

Affecting approximately 500,000 people in the United States annually, *Clostridioides difficile* infection (CDI) is a significant health threat [1.8.1]. When asking, 'What is the strongest medicine for C. diff?', it's crucial to consider the infection's severity and whether it's an initial or recurrent episode.

For most systemic infections, intravenous vancomycin is discontinued abruptly once the course is complete, but for recurrent *Clostridioides difficile* infections, a tapered oral regimen is the standard of care. So, do you have to taper off vancomycin? The answer is nuanced and depends entirely on the type of infection and the route of administration.